Selected Publications:

Osaki LH, Bockerstett KA, Wong CF, Ford EL, Madison BB, DiPaolo RJ, Mills JC. (2019) Interferon-γ directly induces gastric epithelial cell death and is required for progression to metaplasia. J Pathol, Apr;247(4):513-523. PMID 30511397

Saenz JB, Vargas N, Mills JC. (2019) Tropism for spasmolytic polypeptide-expressing metaplasia allows helicobacter pylori to expand its intra-gastric niche. Gastroenterology, Jan;156(1):160-174.e7. PMID: 30287170

Burclaff J, Mills JC. (2018) Plasticity of differentiated cells in wound repair and tumorigenesis, part II: skin and intestine. Dis Model Mech, Aug 31;11(9). PMID: 30171151

Burclaff J, Mills JC. (2018) Plasticity of differentiated cells in wound repair and tumorigenesis, part I: stomach and pancreas. Dis Model Mech, Jul 23;11(7). PMID: 30037967

Willet SG, Lewis MA, Miao ZF, Liu D, Radyk MD, Cunningham RL, Burclaff J, Sibbel G, Lo HG, Blanc V, Davidson NO, Wang ZN, Mills JC. (2018) Regenerative proliferation of differentiated cells by mTORC1-dependent paligenosis. The EMBO Journal, Apr 3;37(7). PMID: 29467218

Saenz JB, Mills JC. (2018) Acid and the basis for cellular plasticity and reprogramming in gastric repair and cancer. Nat. Rev. Gastroenterol. Hepatol. May;15(5):257-273. PMID:29463907

Radyk MD, Burclaff J, Willet SG, Mills JC. (2018) Metaplastic cells in the stomach arise, independently of stem cells, via dedifferentiation or transdifferentiation of chief cells. Gastroenterology, Mar;154(4):839-843.e2. PMID:29248442

Lo HG, Jin RU, Sibbel G, Liu D, Karki A, Jones MS, Madison BB, Zhang B, Blanc V, Fitzpatrick JA, Davidson NO, Konieczny SF, Mills JC. (2017) A single transcription factor is sufficient to induce and maintain secretory cell architecture. Genes Dev, 31(2):154-171. PMID:28174210

Burclaff J, Osaki LH, Liu D, Goldenring JR, Mills JC. (2017) Targeted apoptosis of parietal cells is insufficient to induce metaplasia in stomach. Gastroenterology, (16)35446-4. PMID:27932312

Willet SG, Mills JC. (2016) Stomach organ and cell lineage differentiation: from embryogenesis to adult homeostasis. Cell Mol Gastroenterol Hepatol, 2(5):546-559. PMID:27642625

Moore BD, Jin RU, Lo H, Jung M, Wang H, Battle MA, Wollheim CB, Urano F, Mills JC. (2016) Transcriptional regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4Α) is vital to beta-cell function. J Biol Chem, 291:6146-6157. PMID:26792861

Saenz JB, Burclaff J, Mills JC. (2016) Modeling murine gastric metaplasia through tamoxifen-induced acute parietal cell loss. Methods Mol Biol, 1422:329-39. PMID:27246044

Mills JC, Sansom OJ. (2015) Reserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract. Sci Signal, 8(385):re8. PMID:26175494

Jin RU, Mills JC. (2014) RAB26 coordinates lysosome traffic and mitochondrial localization. J Cell Sci, 127:1018-1032. PMID:24413166

Stange DE, Koo B-K, Huch M, Sibbel G, Basak O, Lyubimova A, Kujala P, Bartfeld S, Koster J, Geahlen JH, Peters PJ, van Es JH, van de Wetering M, Mills JC, Clevers H. (2013) Differentiated Troy+ chief cells act as “reserve” stem cells to generate all lineages of the stomach epithelium. Cell, 155:357-368. PMID:24120136

Khurana SS, Riehl TE, Moore BD, Fassan M, Rugge M, Romero-Gallo J, Noto J, Peek RM, Stenson WF, Mills JC. (2013) The hyaluronic acid receptor CD44 coordinates normal and metaplastic gastric epithelial progenitor cell proliferation. J Biol Chem, 288:16085-16097. PMID:23589310 (selected for cover illustration)

Mills JC, Taghert PH. (2012) Scaling factors: Transcription factors regulating subcellular domains. Bioessays, 34:10-16. PMID:22028036